Introducción El cidofovir es un antiviral que inhibe la ADN-polimerasa de diferentes virus. Ha sido utilizado en infecciones originadas por el virus del papiloma humano. Métodos Estudio retrospectivo descriptivo en el que se incluyó a pacientes con verrugas anogenitales resistentes a terapias convencionales sobre las que se aplicó cidofovir crema. Resultados Se trataron 9 pacientes inmunocompetentes, con respuesta completa en 6 y parcial en 3.ConclusiónEl cidofovir podría ser una alternativa útil, aunque se precisan más estudios que establezcan su mejor posología y su coste-eficacia (AU)
Background Cidofovir is an antiviral agent which inhibits the DNA polymerase of different viruses. Its use has been described for papillomavirus infections. Methods Descriptive retrospective study, including patients with difficult to treat anogenital warts who were treated with cidofovir cream. Results Nine immunocompetent patients were treated, where 6 of them had a complete response and 3 of them a partial response. Conclusion Cidofovir cream could be a useful therapeutic alternative, although further studies are required to establish the best dosage and its cost-effectiveness (AU)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Young Adult , Adult , Condylomata Acuminata/drug therapy , Papillomaviridae/isolation & purification , Antiviral Agents/therapeutic use , Retrospective Studies , Administration, Topical
BACKGROUND: Cidofovir is an antiviral agent which inhibits the DNA polymerase of different viruses. Its use has been described for papillomavirus infections. METHODS: Descriptive retrospective study, including patients with difficult to treat anogenital warts who were treated with cidofovir cream. RESULTS: Nine immunocompetent patients were treated, where 6 of them had a complete response and 3 of them a partial response. CONCLUSION: Cidofovir cream could be a useful therapeutic alternative, although further studies are required to establish the best dosage and its cost-effectiveness.
Antiviral Agents/therapeutic use , Anus Diseases/drug therapy , Condylomata Acuminata/drug therapy , Cytosine/analogs & derivatives , Genital Diseases, Male/drug therapy , Organophosphonates/therapeutic use , Administration, Topical , Adult , Aminoquinolines/therapeutic use , Antiviral Agents/administration & dosage , Anus Diseases/surgery , Child , Cidofovir , Combined Modality Therapy , Condylomata Acuminata/surgery , Cryotherapy , Cytosine/administration & dosage , Cytosine/therapeutic use , Disease Susceptibility , Drug Evaluation , Drug Resistance, Viral , Electrocoagulation , Female , Genital Diseases, Female/drug therapy , Genital Diseases, Female/surgery , Genital Diseases, Male/surgery , Humans , Imiquimod , Immunocompetence , Male , Organophosphonates/administration & dosage , Podophyllotoxin/therapeutic use , Remission Induction , Retrospective Studies , Young Adult
